A novel systemically administered toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models

Although topical TLR7 therapies such as imiquimod have proved successful in the treatment of dermatological malignancy, systemic delivery may be required for optimal immunotherapy of nondermatological tumors. We report that intravenous delivery of the novel small molecule TLR7 agonist, DSR-6434, lea...

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Bibliographic Details
Published in:Int J Cancer
Main Authors: Adlard, Amy L, Dovedi, Simon J, Telfer, Brian A, Koga-Yamakawa, Erina, Pollard, Charlotte, Honeychurch, Jamie, Illidge, Timothy M, Murata, Masashi, Robinson, David T, Jewsbury, Philip J, Wilkinson, Robert W, Stratford, Ian J
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
Subjects:
Tumor Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286010/
https://ncbi.nlm.nih.gov/pubmed/24390981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.28711
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