The Role of Osteopontin and Tumor Necrosis Factor Alpha Receptor-1 in Xenobiotic-induced Cholangitis and Biliary Fibrosis in Mice

BACKGROUND & AIMS: Proinflammatory and profibrotic cytokines such as osteopontin (OPN) and tumor necrosis factor-alpha receptor 1 (TNFR(1)) may be critically involved in the pathogenesis of cholangiopathies and biliary fibrosis. We therefore aimed to determine the role of genetic loss of either...

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Опубликовано в: :Lab Invest
Главные авторы: Fickert, Peter, Thueringer, Andrea, Moustafa, Tarek, Silbert, Dagmar, Gumhold, Judith, Tsybrovskyy, Oleksiy, Lebofsky, Margitta, Jaeschke, Hartmut, Denk, Helmut, Trauner, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285781/
https://ncbi.nlm.nih.gov/pubmed/20368698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2010.61
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