ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8(+) T Cells

Cancer vaccines aim to induce CTL responses against tumors. Challenges for vaccine design are targeting Ag to dendritic cells (DCs) in vivo, facilitating cross-presentation, and conditioning the microenvironment for Th1 type immune responses. In this study, we report that ISCOM vaccines, which consi...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Duewell, Peter, Kisser, Ulrich, Heckelsmiller, Klaus, Hoves, Sabine, Stoitzner, Patrizia, Koernig, Sandra, Morelli, Adriana B., Clausen, Björn E., Dauer, Marc, Eigler, Andreas, Anz, David, Bourquin, Carole, Maraskovsky, Eugene, Endres, Stefan, Schnurr, Max
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285562/
https://ncbi.nlm.nih.gov/pubmed/21613613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1004114
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