E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role

Ischemia/reperfusion (I/R) elicits renin release from cardiac mast cells (MC), thus activating a local renin-angiotensin system (RAS), culminating in ventricular fibrillation. We hypothesized that in I/R, neurogenic ATP could degranulate juxtaposed MC and that ecto-nucleoside triphosphate diphosphoh...

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Publicat a:FASEB J
Autors principals: Aldi, Silvia, Marino, Alice, Tomita, Kengo, Corti, Federico, Anand, Ranjini, Olson, Kim E., Marcus, Aaron J., Levi, Roberto
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2015
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285537/
https://ncbi.nlm.nih.gov/pubmed/25318477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-261867
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