Histamine H(4)-Receptors Inhibit Mast Cell Renin Release in Ischemia/Reperfusion via Protein Kinase Cε-Dependent Aldehyde Dehydrogenase Type-2 Activation

Renin released by ischemia/reperfusion (I/R) from cardiac mast cells (MCs) activates a local renin-angiotensin system (RAS) causing arrhythmic dysfunction. Ischemic preconditioning (IPC) inhibits MC renin release and consequent activation of this local RAS. We postulated that MC histamine H(4)-recep...

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Detalhes bibliográficos
Main Authors: Aldi, Silvia, Takano, Ken-ichi, Tomita, Kengo, Koda, Kenichiro, Chan, Noel Y.-K., Marino, Alice, Salazar-Rodriguez, Mariselis, Thurmond, Robin L., Levi, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019319/
https://ncbi.nlm.nih.gov/pubmed/24696042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.214122
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