Aldehyde Dehydrogenase Type 2 Activation by Adenosine and Histamine Inhibits Ischemic Norepinephrine Release in Cardiac Sympathetic Neurons: Mediation by Protein Kinase Cε

During myocardial ischemia/reperfusion, lipid peroxidation leads to the formation of toxic aldehydes that contribute to ischemic dysfunction. Mitochondrial aldehyde dehydrogenase type 2 (ALDH2) alleviates ischemic heart damage and reperfusion arrhythmias via aldehyde detoxification. Because excessiv...

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Detalhes bibliográficos
Main Authors: Robador, Pablo A., Seyedi, Nahid, Chan, Noel Yan-Ki, Koda, Kenichiro, Levi, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464041/
https://ncbi.nlm.nih.gov/pubmed/22761303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.196626
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