Retrospective Review of Combined Sirolimus and Simvastatin Therapy in Lymphangioleiomyomatosis

BACKGROUND: Combined simvastatin and sirolimus therapy reduces tuberous sclerosis complex 2-null lesions and alveolar destruction in a mouse model of lymphangioleiomyomatosis (LAM), suggesting that therapy with both drugs may benefit patients with LAM. METHODS: To determine whether simvastatin chang...

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Udgivet i:Chest
Main Authors: Taveira-DaSilva, Angelo M., Jones, Amanda M., Julien-Williams, Patricia A., Stylianou, Mario, Moss, Joel
Format: Artigo
Sprog:Inglês
Udgivet: American College of Chest Physicians 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285076/
https://ncbi.nlm.nih.gov/pubmed/25167325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1378/chest.14-0758
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