RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: A mechanism for diabetes-associated erectile dysfunction

Significant impairment in endothelial-derived nitric oxide is present in the diabetic corpus cavernosum. RhoA/Rho-kinase may suppress endothelial nitric oxide synthase (eNOS). Here, we tested the hypothesis that RhoA/Rho-kinase contributes to diabetes-related erectile dysfunction and down-regulation...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Bivalacqua, Trinity J., Champion, Hunter C., Usta, Mustafa F., Cellek, Selim, Chitaley, Kanchan, Webb, R. Clinton, Lewis, Ronald L., Mills, Thomas M., Hellstrom, Wayne J. G., Kadowitz, Philip J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC428483/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15184671/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400520101
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