Genome-wide analysis of the human p53 transcriptional network unveils a lncRNA tumour suppressor signature

Despite the inarguable relevance of p53 in cancer, genome-wide studies relating endogenous p53 activity to the expression of lncRNAs in human cells are still missing. Here, by integrating RNA-seq with p53 ChIP-seq analyses of a human cancer cell line under DNA damage, we define a high-confidence set...

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Udgivet i:Nat Commun
Main Authors: Sánchez, Yolanda, Segura, Victor, Marín-Béjar, Oskar, Athie, Alejandro, Marchese, Francesco P., González, Jovanna, Bujanda, Luis, Guo, Shuling, Matheu, Ander, Huarte, Maite
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284803/
https://ncbi.nlm.nih.gov/pubmed/25524025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6812
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