The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Myc proteins regulate cell growth and division and are implicated in a wide range of human cancers. We show here that Fbw7, a component of the SCF(Fbw7) ubiquitin ligase and a tumor suppressor, promotes proteasome-dependent c-Myc turnover in vivo and c-Myc ubiquitination in vitro. Phosphorylation of...

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書誌詳細

出版年:	Proc Natl Acad Sci U S A
主要な著者:	Welcker, Markus, Orian, Amir, Jin, Jianping, Grim, Jonathan A., Harper, J. Wade, Eisenman, Robert N., Clurman, Bruce E.
フォーマット:	Artigo
言語:	Inglês
出版事項:	National Academy of Sciences 2004
主題:	Biological Sciences
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC428477/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15150404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402770101
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