Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism
<p>hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp–Cullin–F-box) ubiquitin ligases and thereby regulates the degradation of potent oncogenes such as cyclin E, Myc, c-Jun and Notch. Mutations in the hCDC4 gene have been found...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Ivyspring International Publisher
2006-01-01
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| Schriftenreihe: | International Journal of Medical Sciences |
| Online-Zugang: | http://www.medsci.org/v03p0148.htm |
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