Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphism
<p>hCDC4 (FBW7, FBXW7) is a new potential tumor suppressor gene which provides substrate specificity for SCF (Skp–Cullin–F-box) ubiquitin ligases and thereby regulates the degradation of potent oncogenes such as cyclin E, Myc, c-Jun and Notch. Mutations in the hCDC4 gene have been found...
Αποθηκεύτηκε σε:
| Κύριος συγγραφέας: | |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Ivyspring International Publisher
2006-01-01
|
| Σειρά: | International Journal of Medical Sciences |
| Διαθέσιμο Online: | http://www.medsci.org/v03p0148.htm |
| Ετικέτες: |
Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!
|