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A Biomimetic Strategy to Access the Silybins: Total Synthesis of (−)-Isosilybin A

[Image: see text] We report the first asymmetric, total synthesis of (−)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the...

詳細記述

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書誌詳細
出版年:Org Lett
主要な著者: McDonald, Benjamin R., Nibbs, Antoinette E., Scheidt, Karl A.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284651/
https://ncbi.nlm.nih.gov/pubmed/25517432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol503303w
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