The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction

Alzheimer’s dementia is a devastating and incurable disease afflicting over 35 million people worldwide. Amyloid-β (Aβ), a key pathogenic factor in this disease, has potent cerebrovascular effects that contribute to brain dysfunction underlying dementia by limiting the delivery of oxygen and glucose...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Park, L., Wang, G., Moore, J., Girouard, H., Zhou, P., Anrather, J., Iadecola, C.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283829/
https://ncbi.nlm.nih.gov/pubmed/25351853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6318
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