Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

Stromal communication with cancer cells can influence treatment response. We show that stromal and breast cancer (BrCa) cells utilize paracrine and juxtacrine signaling to drive chemotherapy and radiation resistance. Upon heterotypic interaction, exosomes are transferred from stromal to BrCa cells....

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Boelens, Mirjam C., Wu, Tony J., Nabet, Barzin Y., Xu, Bihui, Qiu, Yu, Yoon, Taewon, Azzam, Diana J., Twyman-Saint Victor, Christina, Wiemann, Brianne Z., Ishwaran, Hemant, ter Brugge, Petra J., Jonkers, Jos, Slingerland, Joyce, Minn, Andy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283810/
https://ncbi.nlm.nih.gov/pubmed/25417103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.09.051
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