Tfap2a-dependent changes in mouse facial morphology result in clefting that can be ameliorated by a reduction in Fgf8 gene dosage

Failure of facial prominence fusion causes cleft lip and palate (CL/P), a common human birth defect. Several potential mechanisms can be envisioned that would result in CL/P, including failure of prominence growth and/or alignment as well as a failure of fusion of the juxtaposed epithelial seams. He...

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Publicado en:Dis Model Mech
Autores principales: Green, Rebecca M., Feng, Weiguo, Phang, Tzulip, Fish, Jennifer L., Li, Hong, Spritz, Richard A., Marcucio, Ralph S., Hooper, Joan, Jamniczky, Heather, Hallgrímsson, Benedikt, Williams, Trevor
Formato: Artigo
Lenguaje:Inglês
Publicado: The Company of Biologists Limited 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283648/
https://ncbi.nlm.nih.gov/pubmed/25381013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.017616
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