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Thiol-Disulfide Exchange in Peptides Derived from Human Growth Hormone

Disulfide bonds stabilize proteins by crosslinking distant regions into a compact three-dimensional structure. They can also participate in hydrolytic and oxidative pathways to form non-native disulfide bonds and other reactive species. Such covalent modifications can contribute to protein aggregati...

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Bibliographic Details
Published in:J Pharm Sci
Main Authors: Chandrasekhar, Saradha, Epling, Daniel E., Sophocleous, Andreas M., Topp, Elizabeth M.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283463/
https://ncbi.nlm.nih.gov/pubmed/24549831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23906
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