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A dystrophic muscle broadens the contribution and activation of immune cells reacting to rAAV gene transfer

Recombinant adeno-associated viral vectors (rAAVs) are used for therapeutic gene transfer in skeletal muscle, but it is unclear if immune reactivity to gene transfer and persistence of transgene are affected by pathologic conditions such as muscular dystrophy. Thus, we compared dystrophic mice devoi...

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Publicat a:Gene Ther
Autors principals: Ferrand, M, Galy, A, Boisgerault, F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283385/
https://ncbi.nlm.nih.gov/pubmed/25030611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2014.61
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