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Effect of a neutrophil elastase inhibitor on ventilator-induced lung injury in rats

OBJECTIVE: We hypothesized that pretreatment with sivelestat therapy could attenuate ventilator-induced lung injury (VILI) and lung inflammation in a rat model. METHODS: The neutrophil elastase inhibitor was administered intraperitoneally 30 min before and at the initiation of ventilation. The rats...

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Библиографические подробности
Опубликовано в: :J Thorac Dis
Главные авторы: Kim, Do-Hyung, Chung, Jae Ho, Son, Bong Soo, Kim, Yeon Ji, Lee, Sang Gwon
Формат: Artigo
Язык:Inglês
Опубликовано: Pioneer Bioscience Publishing Company 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283296/
https://ncbi.nlm.nih.gov/pubmed/25589960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2072-1439.2014.11.10
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