The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells

The unfolded protein response (UPR) is a conserved stress-signaling pathway activated after accumulation of unfolded proteins within the endoplasmic reticulum (ER). Active UPR signaling leads to unconventional, enzymatic splicing of XBP1 mRNA enabling expression of the transcription factor XBP1s to...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Jurkin, Jennifer, Henkel, Theresa, Nielsen, Anne Færch, Minnich, Martina, Popow, Johannes, Kaufmann, Therese, Heindl, Katrin, Hoffmann, Thomas, Busslinger, Meinrad, Martinez, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282640/
https://ncbi.nlm.nih.gov/pubmed/25378478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201490332
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