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Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews
PURPOSE: Cisplatin induces nausea and emesis, even with antiemetic supportive care. To assess platinum exposure, which could activate nausea and emesis, we quantitated platinum in the brain and various organs, and hindbrain and spinal cord substance P, a key neuropeptide for the neuronal signaling o...
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| Опубликовано в: : | Cancer Chemother Pharmacol |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4282608/ https://ncbi.nlm.nih.gov/pubmed/25398697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2623-5 |
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