Plasma pharmacokinetics and tissue and brain distribution of cisplatin in musk shrews

PURPOSE: Cisplatin induces nausea and emesis, even with antiemetic supportive care. To assess platinum exposure, which could activate nausea and emesis, we quantitated platinum in the brain and various organs, and hindbrain and spinal cord substance P, a key neuropeptide for the neuronal signaling o...

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Published in:Cancer Chemother Pharmacol
Main Authors: Eiseman, Julie L., Beumer, Jan H., Rigatti, Lora H., Strychor, Sandra, Meyers, Kelly, Dienel, Samuel, Horn, Charles C.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282608/
https://ncbi.nlm.nih.gov/pubmed/25398697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2623-5
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