Parkin-independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

Mitochondrial dynamics and mitophagy have been linked to cardiovascular and neurodegenerative diseases. Here, we demonstrate that the mitochondrial division dynamin Drp1 and the Parkinson's disease-associated E3 ubiquitin ligase parkin synergistically maintain the integrity of mitochondrial str...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Kageyama, Yusuke, Hoshijima, Masahiko, Seo, Kinya, Bedja, Djahida, Sysa-Shah, Polina, Andrabi, Shaida A, Chen, Weiran, Höke, Ahmet, Dawson, Valina L, Dawson, Ted M, Gabrielson, Kathleen, Kass, David A, Iijima, Miho, Sesaki, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282557/
https://ncbi.nlm.nih.gov/pubmed/25349190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488658
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