Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon

TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are required for robust formation of primary cilia. We further discover the existence of primary cilia in colon and demonstrate that TTLL3 is the o...

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Vydáno v:EMBO J
Hlavní autoři: Rocha, Cecilia, Papon, Laura, Cacheux, Wulfran, Marques Sousa, Patricia, Lascano, Valeria, Tort, Olivia, Giordano, Tiziana, Vacher, Sophie, Lemmers, Benedicte, Mariani, Pascale, Meseure, Didier, Medema, Jan Paul, Bièche, Ivan, Hahne, Michael, Janke, Carsten
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282510/
https://ncbi.nlm.nih.gov/pubmed/25180231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488466
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