Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon

TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are required for robust formation of primary cilia. We further discover the existence of primary cilia in colon and demonstrate that TTLL3 is the o...

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Udgivet i:EMBO J
Main Authors: Rocha, Cecilia, Papon, Laura, Cacheux, Wulfran, Marques Sousa, Patricia, Lascano, Valeria, Tort, Olivia, Giordano, Tiziana, Vacher, Sophie, Lemmers, Benedicte, Mariani, Pascale, Meseure, Didier, Medema, Jan Paul, Bièche, Ivan, Hahne, Michael, Janke, Carsten
Format: Artigo
Sprog:Inglês
Udgivet: BlackWell Publishing Ltd 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282510/
https://ncbi.nlm.nih.gov/pubmed/25180231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201488466
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