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Empirical Bayes estimation of the selected treatment mean for two-stage drop-the-loser trials: a meta-analytic approach

Point estimation for the selected treatment in a two-stage drop-the-loser trial is not straightforward because a substantial bias can be induced in the standard maximum likelihood estimate (MLE) through the first stage selection process. Research has generally focused on alternative estimation strat...

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Pubblicato in:Stat Med
Autori principali: Bowden, Jack, Brannath, Werner, Glimm, Ekkehard
Natura: Artigo
Lingua:Inglês
Pubblicazione: BlackWell Publishing Ltd 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282323/
https://ncbi.nlm.nih.gov/pubmed/23873666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5920
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