Antihelminthic Benzimidazoles Are Novel HIF Activators That Prevent Oxidative Neuronal Death via Binding to Tubulin

Aims: Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened a drug library with known safety in humans using a hippocampal neurob...

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Veröffentlicht in:Antioxid Redox Signal
Hauptverfasser: Aleyasin, Hossein, Karuppagounder, Saravanan S., Kumar, Amit, Sleiman, Sama, Basso, Manuela, Ma, Thong, Siddiq, Ambreena, Chinta, Shankar J., Brochier, Camille, Langley, Brett, Haskew-Layton, Renee, Bane, Susan L., Riggins, Gregory J., Gazaryan, Irina, Starkov, Anatoly A., Andersen, Julie K., Ratan, Rajiv R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Forum Original Research CommunicationsStroke (S. Cho and R. R. Ratan, Eds.)
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281859/
https://ncbi.nlm.nih.gov/pubmed/24766300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5595
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