Clinical Implications of Detectable Baseline Hepatitis C Virus-Genotype 1 NS3/4A-Protease Variants on the Efficacy of Boceprevir Combined With Peginterferon/Ribavirin

BACKGROUND:  We analyzed the impact of pretreatment variants conferring boceprevir-resistance on sustained virologic response (SVR) rates achieved with boceprevir plus peginterferon-α/ribavirin (P/R) for hepatitis C virus (HCV)-genotype-1 infection. METHODS:  NS3-protease-polymorphisms emerging coin...

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Publicat a:Open Forum Infect Dis
Autors principals: Howe, John A., Long, Jianmin, Black, Stuart, Chase, Robert, McMonagle, Patricia, Curry, Stephanie, Thompson, Seth, DiNubile, Mark J., Howe, Anita Y. M.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Major Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281806/
https://ncbi.nlm.nih.gov/pubmed/25734146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofu078
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