The First Crystal Structure of a dTTP-bound Deoxycytidylate Deaminase Validates and Details the Allosteric-Inhibitor Binding Site

Deoxycytidylate deaminase is unique within the zinc-dependent cytidine deaminase family as being allosterically regulated, activated by dCTP, and inhibited by dTTP. Here we present the first crystal structure of a dTTP-bound deoxycytidylate deaminase from the bacteriophage S-TIM5, confirming that th...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Marx, Ailie, Alian, Akram
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281768/
https://ncbi.nlm.nih.gov/pubmed/25404739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.617720
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