Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function

Vascular remodeling is essential for tissue repair and is regulated by multiple factors, including thrombospondin-2 (TSP2) and hypoxia/VEGF-induced activation of Akt. In contrast to TSP2 knock-out (KO) mice, Akt1 KO mice have elevated TSP2 expression and delayed tissue repair. To investigate the con...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Bancroft, Tara, Bouaouina, Mohamed, Roberts, Sophia, Lee, Monica, Calderwood, David A., Schwartz, Martin, Simons, Michael, Sessa, William C., Kyriakides, Themis R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281743/
https://ncbi.nlm.nih.gov/pubmed/25389299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.618421
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