Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition

Airway dehydration causes mucus stasis and bacterial overgrowth in cystic fibrosis and chronic bronchitis (CB). Rehydration by hypertonic saline is efficacious but suffers from a short duration of action. We tested whether epithelial sodium channel (ENaC) inhibition would rehydrate normal and dehydr...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Åstrand, Annika B. M., Hemmerling, Martin, Root, James, Wingren, Cecilia, Pesic, Jelena, Johansson, Edvin, Garland, Alaina L., Ghosh, Arunava, Tarran, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281700/
https://ncbi.nlm.nih.gov/pubmed/25361567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00163.2014
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