p38 MAPK activation upregulates proinflammatory pathways in skeletal muscle cells from insulin-resistant type 2 diabetic patients

Skeletal muscle is the key site of peripheral insulin resistance in type 2 diabetes. Insulin-stimulated glucose uptake is decreased in differentiated diabetic cultured myotubes, which is in keeping with a retained genetic/epigenetic defect of insulin action. We investigated differences in gene expre...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: Brown, Audrey E., Palsgaard, Jane, Borup, Rehannah, Avery, Peter, Gunn, David A., De Meyts, Pierre, Yeaman, Stephen J., Walker, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281683/
https://ncbi.nlm.nih.gov/pubmed/25370850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00115.2014
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