A pharmacokinetic and pharmacodynamic investigation of Modufolin(®) compared to Isovorin(®) after single dose intravenous administration to patients with colon cancer: a randomized study

PURPOSE: Leucovorin is commonly used as folate supplement in 5-fluorouracil-based chemotherapy, but needs to be converted to active 5,10-methylenetetrahydrofolate (methyleneTHF) intracellularly. This provides for interindividual differences. MethyleneTHF has recently been developed into the stable,...

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Publicat a:Cancer Chemother Pharmacol
Autors principals: Wettergren, Yvonne, Taflin, Helena, Odin, Elisabeth, Kodeda, Karl, Derwinger, Kristoffer
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281361/
https://ncbi.nlm.nih.gov/pubmed/25342290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2611-9
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