The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT(1A) receptor signaling: mechanistic studies

RATIONALE: Diverse preclinical studies suggest the potential therapeutic utility of the modulation of the glutamatergic system in brain via metabotropic glutamate (mGlu) receptors. Lu AF21934, a positive allosteric modulator of the mGlu4 receptor, was previously shown to reverse behavioral phenotype...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Wierońska, Joanna M., Sławińska, Anna, Łasoń-Tyburkiewicz, Magdalena, Gruca, Piotr, Papp, Mariusz, Zorn, Stevin H., Doller, Darío, Kłeczek, Natalia, Noworyta-Sokołowska, Karolina, Gołembiowska, Krystyna, Pilc, Andrzej
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2014
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281359/
https://ncbi.nlm.nih.gov/pubmed/25012236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-014-3657-4
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