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The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung

Necrotic cell death in vivo induces a robust neutrophilic inflammatory response and the resulting inflammation can cause further tissue damage and disease. Dying cells induce this inflammation by releasing pro-inflammatory intracellular components, one of which is uric acid. Cells contain high level...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Kataoka, Hiroshi, Yang, Ke, Rock, Kenneth L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281294/
https://ncbi.nlm.nih.gov/pubmed/25449036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.11.013
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