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Bridging of a substrate between cyclodextrin and an enzyme’s active site pocket triggers a unique mode of inhibition
BACKGROUND: Methionyl-7-amino-4-methylcoumarin (MetAMC) serves as a substrate for the E. coli Methionine aminopeptidase (MetAP) catalyzed reaction, and is routinely used for screening compounds to identify potential antibiotic agents. In pursuit of screening the enzyme’s inhibitors, we observed that...
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| Udgivet i: | Biochim Biophys Acta |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281286/ https://ncbi.nlm.nih.gov/pubmed/25450177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2014.10.016 |
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