Functional Mapping of Protein-Protein Interactions in an Enzyme Complex by Directed Evolution

The shikimate pathway enzyme chorismate mutase converts chorismate into prephenate, a precursor of Tyr and Phe. The intracellular chorismate mutase (MtCM) of Mycobacterium tuberculosis is poorly active on its own, but becomes >100-fold more efficient upon formation of a complex with the first enz...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Roderer, Kathrin, Neuenschwander, Martin, Codoni, Giosiana, Sasso, Severin, Gamper, Marianne, Kast, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281200/
https://ncbi.nlm.nih.gov/pubmed/25551646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116234
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