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Epistasis as a Determinant of the HIV-1 Protease's Robustness to Mutation
The robustness of phenotypes to mutation is critical to protein evolution; robustness may be an adaptive trait if it promotes evolution. We hypothesised that native proteins subjected to natural selection in vivo should be more robust than proteins generated in vitro in the absence of natural select...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281083/ https://ncbi.nlm.nih.gov/pubmed/25551558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0116301 |
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