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Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling
BACKGROUND AND PURPOSE: H(2)O(2) is widely understood to regulate intracellular signalling. In airway epithelia, H(2)O(2) stimulates anion secretion primarily by activating an autocrine PGE(2) signalling pathway via EP(4) and EP(1) receptors to initiate cytic fibrosis transmembrane regulator (CFTR)-...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280976/ https://ncbi.nlm.nih.gov/pubmed/25220136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12934 |
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