Diazido Mixed-Amine Platinum(IV) Anticancer Complexes Activatable by Visible-Light Form Novel DNA Adducts

Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable Pt(IV) prodrugs offer the potential of targeted drug release and new mechanisms of action. We report the synthesis, X-ray crystallographic and...

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發表在:Chemistry
Main Authors: Zhao, Yao, Woods, Julie A, Farrer, Nicola J, Robinson, Kim S, Pracharova, Jitka, Kasparkova, Jana, Novakova, Olga, Li, Huilin, Salassa, Luca, Pizarro, Ana M, Clarkson, Guy J, Song, Lijiang, Brabec, Viktor, Sadler, Peter J
格式: Artigo
語言:Inglês
出版: WILEY-VCH Verlag 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280898/
https://ncbi.nlm.nih.gov/pubmed/23733242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201300374
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