Subcellular Distribution and Activity of Mechanistic Target of Rapamycin in Aged Retinal Pigment Epithelium

PURPOSE. Inhibiting mechanistic target of rapamycin (mTOR) by pharmacological or genetic approaches can extend lifespan in mammals. The kinase activity of mTOR is controlled by upstream regulatory proteins and its subcellular localization. The purpose of this study was to characterize age-related al...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Yu, Bo, Xu, Pei, Zhao, Zhenyang, Cai, Jiyang, Sternberg, Paul, Chen, Yan
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280880/
https://ncbi.nlm.nih.gov/pubmed/25491300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.14-14758
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