Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells

Most inherited forms of blindness are caused by mutations that lead to photoreceptor cell death but spare second- and third-order retinal neurons. Expression of the light-gated excitatory mammalian ion channel light-gated ionotropic glutamate receptor (LiGluR) in retinal ganglion cells (RGCs) of the...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Gaub, Benjamin M., Berry, Michael H., Holt, Amy E., Reiner, Andreas, Kienzler, Michael A., Dolgova, Natalia, Nikonov, Sergei, Aguirre, Gustavo D., Beltran, William A., Flannery, John G., Isacoff, Ehud Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280620/
https://ncbi.nlm.nih.gov/pubmed/25489083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414162111
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