The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation

CAPN3/p94/calpain-3, a calpain protease family member predominantly expressed in skeletal muscle, possesses unusually rapid and exhaustive autolytic activity. Mutations in the human CAPN3 gene impairing its protease functions cause limb-girdle muscular dystrophy type 2A (LGMD2A); yet, the connection...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Ono, Yasuko, Shindo, Mayumi, Doi, Naoko, Kitamura, Fujiko, Gregorio, Carol C., Sorimachi, Hiroyuki
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280609/
https://ncbi.nlm.nih.gov/pubmed/25512505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411959111
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