Association of Low-Density Lipoprotein Cholesterol–Related Genetic Variants With Aortic Valve Calcium and Incident Aortic Stenosis

IMPORTANCE: Plasma low-density lipoprotein cholesterol (LDL-C) has been associated with aortic stenosis in observational studies; however, randomized trials with cholesterol-lowering therapies in individuals with established valve disease have failed to demonstrate reduced disease progression. OBJEC...

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Publicado no:JAMA
Main Authors: Smith, J. Gustav, Luk, Kevin, Schulz, Christina-Alexandra, Engert, James C., Do, Ron, Hindy, George, Rukh, Gull, Dufresne, Line, Almgren, Peter, Owens, David S., Harris, Tamara B., Peloso, Gina M., Kerr, Kathleen F., Wong, Quenna, Smith, Albert V., Budoff, Matthew J., Rotter, Jerome I., Cupples, L. Adrienne, Rich, Stephen, Kathiresan, Sekar, Orho-Melander, Marju, Gudnason, Vilmundur, O’Donnell, Christopher J., Post, Wendy S., Thanassoulis, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280258/
https://ncbi.nlm.nih.gov/pubmed/25344734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2014.13959
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