MiR-29a Reduces TIMP-1 Production by Dermal Fibroblasts via Targeting TGF-β Activated Kinase 1 Binding Protein 1, Implications for Systemic Sclerosis

BACKGROUND: Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterised by skin and internal organs fibrosis due to accumulation of extra cellular matrix (ECM) proteins. Tissue inhibitor of metalloproteinases 1 (TIMP-1) plays a key role in ECM deposition. AIM: To investigate th...

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Bibliographic Details
Published in:PLoS One
Main Authors: Ciechomska, Marzena, O’Reilly, Steven, Suwara, Monika, Bogunia-Kubik, Katarzyna, van Laar, Jacob M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280195/
https://ncbi.nlm.nih.gov/pubmed/25549087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115596
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