Checkpoint Blockade Cancer Immunotherapy Targets Tumour-Specific Mutant Antigens

The immune system plays key roles in determining the fate of developing cancers by not only functioning as a tumour promoter facilitating cellular transformation, promoting tumour growth and sculpting tumour cell immunogenicity(1–6), but also as an extrinsic tumour suppressor that either destroys de...

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Udgivet i:Nature
Main Authors: Gubin, Matthew M., Zhang, Xiuli, Schuster, Heiko, Caron, Etienne, Ward, Jeffrey P., Noguchi, Takuro, Ivanova, Yulia, Hundal, Jasreet, Arthur, Cora D., Krebber, Willem-Jan, Mulder, Gwenn E., Toebes, Mireille, Vesely, Matthew D., Lam, Samuel S.K., Korman, Alan J., Allison, James P., Freeman, Gordon J., Sharpe, Arlene H., Pearce, Erika L., Schumacher, Ton N., Aebersold, Ruedi, Rammensee, Hans-Georg, Melief, Cornelis J. M., Mardis, Elaine R., Gillanders, William E., Artyomov, Maxim N., Schreiber, Robert D.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279952/
https://ncbi.nlm.nih.gov/pubmed/25428507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13988
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