Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo

The polycomb group gene, EZH2, is highly expressed in advanced bladder cancer. Here we demonstrated that down-regulation of EZH2 in tumor tissues after neo-adjuvant chemotherapy correlated with good therapeutic response in advanced bladder cancer. We next developed a small molecule, NSC745885, deriv...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Tang, Shou-Hung, Huang, Hsu-Shan, Wu, Hong-Ui, Tsai, Yi-Ta, Chuang, Mei-Jen, Yu, Cheng-Ping, Huang, Shih-Ming, Sun, Guang-Huan, Chang, Sun-Yran, Hsiao, Pei-Wen, Yu, Dah-Shyong, Cha, Tai-Lung
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2014
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279377/
https://ncbi.nlm.nih.gov/pubmed/25431950
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