Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to γ-irradiation

Radiation therapy is a staple treatment for pancreatic cancer. However, owing to the intrinsic radioresistance of pancreatic cancer cells, radiation therapy often fails to increase survival of pancreatic cancer patients. Radiation impedes cancer cells by inducing DNA damage, which can activate cell...

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Vydáno v:Oncotarget
Hlavní autoři: Yan, Ying, Hein, Ashley L., Etekpo, Asserewou, Burchett, Katrina M., Lin, Chi, Enke, Charles A., Batra, Surinder K., Cowan, Kenneth H., Ouellette, Michel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
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Priority Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279370/
https://ncbi.nlm.nih.gov/pubmed/25344910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.2500
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