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Probing the Kinetic Stabilities of Friedreich’s Ataxia Clinical Variants Using a Solid Phase GroEL Chaperonin Capture Platform

Numerous human diseases are caused by protein folding defects where the protein may become more susceptible to degradation or aggregation. Aberrant protein folding can affect the kinetic stability of the proteins even if these proteins appear to be soluble in vivo. Experimental discrimination betwee...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Correia, Ana R., Naik, Subhashchandra, Fisher, Mark T., Gomes, Cláudio M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279165/
https://ncbi.nlm.nih.gov/pubmed/25333765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom4040956
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