Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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Pubblicato in:PLoS One
Autori principali: Mehta, Ojas H., Norheim, Gunnstein, Hoe, J . Claire, Rollier, Christine S., Nagaputra, Jerry C., Makepeace, Katherine, Saleem, Muhammad, Chan, Hannah, Ferguson, David J. P., Jones, Claire, Sadarangani, Manish, Hood, Derek W., Feavers, Ian, Derrick, Jeremy P., Pollard, Andrew J., Moxon, E . Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278719/
https://ncbi.nlm.nih.gov/pubmed/25545241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115713
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