Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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書誌詳細
出版年:PLoS One
主要な著者: Mehta, Ojas H., Norheim, Gunnstein, Hoe, J . Claire, Rollier, Christine S., Nagaputra, Jerry C., Makepeace, Katherine, Saleem, Muhammad, Chan, Hannah, Ferguson, David J. P., Jones, Claire, Sadarangani, Manish, Hood, Derek W., Feavers, Ian, Derrick, Jeremy P., Pollard, Andrew J., Moxon, E . Richard
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278719/
https://ncbi.nlm.nih.gov/pubmed/25545241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115713
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