Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Mehta, Ojas H., Norheim, Gunnstein, Hoe, J . Claire, Rollier, Christine S., Nagaputra, Jerry C., Makepeace, Katherine, Saleem, Muhammad, Chan, Hannah, Ferguson, David J. P., Jones, Claire, Sadarangani, Manish, Hood, Derek W., Feavers, Ian, Derrick, Jeremy P., Pollard, Andrew J., Moxon, E . Richard
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278719/
https://ncbi.nlm.nih.gov/pubmed/25545241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115713
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