Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice

Neisseria meningitidis lipopolysaccharide (LPS) has adjuvant properties that can be exploited to assist vaccine immunogenicity. The modified penta-acylated LPS retains the adjuvant properties of hexa-acylated LPS but has a reduced toxicity profile. In this study we investigated whether two modified...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mehta, Ojas H., Norheim, Gunnstein, Hoe, J . Claire, Rollier, Christine S., Nagaputra, Jerry C., Makepeace, Katherine, Saleem, Muhammad, Chan, Hannah, Ferguson, David J. P., Jones, Claire, Sadarangani, Manish, Hood, Derek W., Feavers, Ian, Derrick, Jeremy P., Pollard, Andrew J., Moxon, E . Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278719/
https://ncbi.nlm.nih.gov/pubmed/25545241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0115713
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