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Assessing adaptation of the cancer kinome in response to targeted therapies

Cancer cells are dependent on protein kinase signaling networks to drive proliferation and to promote survival, and accordingly kinases continue to represent a major target class for development of anti-cancer therapeutics. Kinase inhibitors nevertheless have yielded only limited success with many d...

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Bibliographic Details
Published in:Biochem Soc Trans
Main Authors: Zawistowski, Jon S., Graves, Lee M., Johnson, Gary L.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4278192/
https://ncbi.nlm.nih.gov/pubmed/25109955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20130274
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